Since 1993, Clinical Trials Inc. (CTI) and Dr. Victor Biton have been instrumental in testing and developing new potential medications. CTI has hosted hundreds of clinical trials and assisted in bringing many important medications to market. Below is a list of Dr. Victor Biton’s articles, abstracts, and clinical studies experience.
Biton V. The Treatment of Epilepsy (Shorvon S, Perucca E, Engel J, eds.). 4th ed., John Wiley & Sons, Ltd./Blackwell Publishing, 2016 ( chapter 47: Rufinamide; 615-627).
Sachdeo R, Partiot A, Biton V, Rosenfeld WE, Nohria V, Tompson D, DeRossett 5, Porter RJ. A novel design for a dose finding, safety, and drug interaction study of an antiepileptic drug (retigabine) in early clinical development. Int J Clin Pharmacol Ther; 2014; 52(6 ): 509-518.
Biton V, Gil-Nagel A, Brodie M, DeRossett S, and Nohria V. Safety and tolerability of different titration rates of retigabine (ezogabine) in patients with partial-onset seizures. Epilepsy Res; 2013; 107( 1 ): 138-145.
Biton V, Berkovic S, Abou-Khalil B, Sperling M, Johnson M, and Lu S. Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: A phase 111 randomized, double-blind, placebo-controlled trial. Epilepsia ( online) Nov 8, 2013.
Klein P, Biton V, Dilley D, Barnes M, Schiemann J, Lu S. Safety and tolerability of adjunctive brivaracetam as intravenous infusion or bolus in patients with epilepsy. Epilepsia (online) Nov 81 2013.
Biton V, Shneker B, Naritoku D, Hammer A, Vuong A, Caldwell P, and Messenheimer J. Long-term tolerability and safety of lamotrigine extended-release: Pooled analysis of three clinical trials. Clinical Drug Investigation 2013; 33(5): 359-364.
Biton V. Lacosamide for the Treatment of Partial-Onset Seizures. Expert Rev. Neurother 2012; 12(6): 645-655.
Sandercock D, Cramer M, Biton V, Cowles VE. A Gastroretentive Gabapentin Formulation for the Treatment of Painful Diabetic Peripheral Neuropathy: Efficacy and Tolerability in a DoubleBlind, Randomized, Controlled Clinical Trial. Diabetes Res Clin Pract 2012; Apr 10. (Epub ahead of print]
Biton V, Krauss G, Vasquez-Santana B, Bibbiani F, Mann A, Perdomo C, and Narurkar M. A
Randomized, Double-blind, Placebo-Controlled, Parallel-Group Study of Rufinamide as Adjunctive Therapy for Refractory Partial-Onset Seizures. Epilepsia 2011; 52(2): 234- 242.(Published Online: October 1, 2010. (DOI: 10.1111/j.1528-1167.2009.02729.x)].
Chung S, Sperling M, Biton V, Krauss G, Hebert D, Rudd G, and Doty P. Lacosamide as Adjunctive Therapy for Partial- Onset Seizures: A Randomized Controlled Trial. Epilepsia 2010; 51(6): 958-967 (doi: 10.1111/j.1528- 1167.2009.02496.x).
Biton V. The Treatment of Epilepsy (Shorvon S, Perucca E, Engel J, eds.). 3rd ed., Blackwell Publishing, 2009 ( chapter 51: Rufinamide; 647-657).
Sandercock D, Cramer M, Wu J, Chiang Y, Biton V, Heritier M. Gabapentin Extended Release for the Treatment of Painful Diabetic Peripheral Neuropathy: Efficacy and Tolerability in a Double-blind, Randomized, Controlled Clinical Trial. Diabetes Care (online) Feb 2009; 32 (2).
Biton V. Lamotrigine for Pediatric Patients with Epilepsy. Pediatric Health 2008; 2 (2): 125-134.
Biton V, Rosenfeld WE, Whitesides J, Fountain NB, Vaiciene N, Rudd GD. Intravenous Lacosamide as Replacement for Oral Lacosamide in Patients with Partial-Onset Seizures. Epilepsia 2008; 49(3): 418-424.
Biton, V. Lacosamide for the Treatment of Diabetic Neuropathic Pain. Expert Review of Neurotherapeutics 2008; 8(11): 1649-1660.
Rauck RL, Shaibani A, Biton V, Simpson J, Koch B. Lacosamide in Painful Diabetic Neuropathy: A Phase 2 Double-Blind Placebo-Controlled Study. Clinical Journal of Pain 2007; 23(2): 150-158.
Biton, V. Clinical Pharmacology and Mechanism of Action of Zonisamide. Clinical Neuropharmacology 2007; 30 (4): 230- 240.
Biton V. Pharmacokinetics, Toxicology, and Safety of Lamotrigine in Epilepsy. Expert Opin Drug Metab Toxicol 2006; 2(6):1009- 1018.
Blum D, Meador K, Biton V, Fakhoury T, Shneker B, Chung S, Mills K, Hammer A, lsojarvi J. Cognitive Effects of Lamotrigine Compared with Topiramate in Patients with Epilepsy. Neurology 2006; 67(3): 400-406.
Biton V. Weight Change and Antiepileptic Drugs: Health Issues and Criteria for Appropriate Selection of an Antiepileptic Agent. Neurologist 2006; 12(3): 163-167.
Biton V, Sackellares JC, Vuong A, Hammer AE, Barrett PS, Messenheimer, JA. Double-Blind, Placebo-Controlled Study of Lamotrigine in Primary Generalized Tonic-Clonic Seizures. Neurology 2005; 65: 1737-1743.
Biton V, Bourgeois BFD. Topiramate in Patients with Juvenile Myoclonic Epilepsy. Archives of Neurology 2005; 62( 11 ): 1705-1708.
Sale ME, Natarajan S, Biton V, Vuong A, Hammer AE, Messenheimer JA, Blum D. A Dosing Algorithm for Converting from Valproate Monotherapy to Lamotrigine Monotherapy in Patients with Epilepsy. Epilepsy and Behavior 2005; 6: 63-70.
Biton V. Zonisamide: New Antiepileptic Agent with Multiple Mechanisms of Action. Expert Rev Neurotherapeutics 2004; 4( 6 ): 935-943.
Biton V. Antiepileptic Drugs and Weight Gain. SYCP Epilepsy 2003; 10(2): 3-6.
Sommerville KW, Dutta S, Biton V, Zhang Y, Cloyd JC, Uthman B. Bioavailability of a Divalproex Extended-Release Formulation versus the Conventional Divalproex Formulation in Adult Patients Receiving Enzyme- Inducing Antiepileptic Drugs. C/in Drug Invest 2003; 23(10): 661- 670.
Leppik IE, Biton V, Sander JW, Wieser HG. Levetiracetam and Partial Seizure Subtypes: Pooled Data From Three Randomized, Placebo-Controlled Trials. Epilepsia 2003; 44 Suppl.12: 1585-1587.
Biton V. Effect of Antipeileptic Drugs on Bodyweight: Overview and Clinical Implications for the Treatment of Epilepsy. CNS Drugs 2003; 17(11): 781-791.
Biton V, Levisohn P, Hoyler S, Vuong A, Hammer AE. Lamotrigine versus Valproate Monotherapy Associated Weight Change in Adolescents with Epilepsy: Results from a Post Hoc Analysis of a Randomized, Double-Blind Clinical Trial. J Child Neuro/ 2003; 18 (2): 133-139.
Gilliam FG, Veloso F, Bomhof MAM, Gazda SK, Biton V, Ter Bruggen JP, Neto W, Bailey C, Pledger G, Wu S-C, Topiramate EPMN 104 Study Group. A Dose-Comparison Trial of Topiramate as Monotherapy in Recently Diagnosed Partial Epilepsy. Neurology 2003; 60: 196-202.
Biton V. Levetiracetam: Adverse Effects. In: Levy RH, Mattson RH, Meldrum BS, Perucca E, eds. Antiepileptic Drugs, 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2002: 442-447.
Biton V, Mirza W, Montouris G, Vuong A, Hammer AE, Barrett PS. Weight Change Associated with Valproate and Lamotrigine Monotherapy in Patients with Epilepsy. Neurology 2001; 56: 172- 177.
Biton V, Edwards K, Montouris G, Sackellares J, Harden C, Kamin M. A Comparison of Titration Rates on Tolerability and Efficacy of Topiramate Initiated as Adjunctive Therapy. Ann Pharmacother 2001; 35: 173-179.
Apfel SC, Schwartz S, Adornato BT, Freeman R, Biton V, Rendell M, Vinik A, Guiliani M, Stevens JC, Barbano R, Dyck P J, rhNGF Clinical Investigator Group. Efficacy and Safety of Recombinant Human Nerve Growth Factor in Patients with Diabetic Polyneuroapthy. JAMA 2000; 284: 2215-2221.
Cereghino JJ, Biton V, Abou-Khalil B, Dreifuss F, Gauer U, Leppik I. Levetiracetam for Partial Seizures: Results of a Double-Blind, Randomized Clinical Trial. Neurology 2000; 55: 236- 242.
Biton V, Montouris GD, Ritter F, Riviello JJ, Reife R, Lim P, Pledger G. A Randomized, Placebo Controlled Study of Topiramate in Primary Generalized Tonic-Clonic Seizures. Neurology 1999; 52: 1330-1337.
Honeycutt J, Boop FA, Biton V, Sharp GB, Griebel ML, Galbraith R. Results of Temporal Lobectomy for the Treatment of Partial Complex Epilepsy. J Ark Med Society 1994; 91(7): 329-333.
Biton V, Gates J, De Padua E. Prolonged Postictal Encephalopathy. Neurology 1990; 40: 963-966.
Biton V, Gates J, Ritter F, Loewenson R. Adjunctive Therapy for Intractable Epilepsy with Ethotoin. Epilepsia 1990 Jul- Aug; 31(4): 433-437.
Melamed E, Biton V, Zelig 0. Episodic Unresponsiveness to Single Doses of L-Dopa in Parkinsonian Fluctuators. Neurology 1986; 36: 100-103.
Melamed E, Biton V, Zelig 0. Delayed Onset of Responses to Single Doses of L-Dopa in Parkinsonian Fluctuators in Long Term L-Dopa Therapy. Clin Neuropharmaco/ 1986; 9(2): 182-188.
Gottlieb D, Fields S, Biton V, Gomori M, Kidron D, Melamed E. Clinical Roentgenological Study of Degenerative Spinocerebellar Diseases. Harefuah (Hebrew) 1986; 111: 165-167.
Biton V, Gomori JM, Gottlieb D, Melamed E. Superior Sagittal Sinus thrombosis: Clinical Picture and Computed Tomographic Findings. Harefuah (Hebrew) 1985; 108: 3-5.
Mathetias O, Soomer H, Biton V. Central Auditory Tests in Multiple Sclerosis. Acta Oto/aryngol 1985; 99: 369-376.
Biton V, Melamed E. Coexistence of Severe Parkinsonism and Tardive Dyskinesia as Side Effects of Neuroleptic Therapy. J Clin Psychiatry 1984; 45: 28-30.
Bramson C, Herrmann D, Biton V, Carey W, Keller D, Brown M, West C, Verburg K, and Dyck P.
Efficacy and Safety of Subcutaneous Tanezumab in Patients With Pain Related to Diabetic Peripheral Neuropathy (NCT01087203). (Presented at the 32nd Annual Meeting of the American Pain Society, May 8- 10, 2013, Tampa, Florida)
Fain R, Yang H, Williams B, Zhou S, Laurenza A, and Biton V. Efficacy and Safety of Perampanel in Patients With Neurologic & Psychiatric Comorbidities: Post-Hoc Analysis of Phase Ill Epilepsy Trials. (Poster presentation at AES, 2013, Washington DC)
Biton V, Krauss G, Blum D, Sousa R, and Grinnell T. Efficacy of eslicarbazepine acetate in patients with refractory partial- onset seizures: a pooled analysis of three Phase 111 controlled studies. (Poster presentation at AES, 2013, Washington DC)
Krauss G, Biton V, Harvey J, Blum D, Sousa R, and Grinnell T. Adverse event profile of eslicarbazepine acetate according to dose titration in Phase Ill controlled studies of patients with refractory partial-onset seizures. (Poster presentation at AES, 2013, Washington DC)
Krauss G, Yang J, Biton V, Klapper J, Bar M, Rektor I. Determination of Maximum Tolerated Dose (MTD), Safety, Efficacy, and Pharmacokinetics (PK) of Perampanel, a Selective AMPA Receptor Antagonist, as Adjunctive Therapy in Subjects with Refractory Partial Seizures. (Abstract presented at the 62nd Annual Meeting of the American Epilepsy Society 2008)
Jatuzis D, Biton V, Ben-Menachem E, Abou-Khalil B, Doty P, Rudd GD. Evaluation of the Effect of Oral Lacosamide on Concomitant AED Plasma Concentrations in Patients with Partial Seizures. Epilepsia 2005; 46 Suppl.8: 170.
Lesser RP, Biton V, Sackellares JC, Van Ness PC, Perdomo C, Arroyo S. Efficacy and Safety of Rufinamide Monotherapy for the Treatment of Patients with Refractory Partial Seizures. Epilepsia 2005; 46 Suppl.8: 177-178.
Rosenfeld W, Biton V, Mameniskiene R, Vaiciene N, Whitesides J, Schiltmeyer B, Sommerville K. Pharmacokinetics and Safety of Intravenous Lacosamide Administered as Replacement for Adjunctive Oral Lacosamide in Patients with Partial-Onset Seizures. Epilepsia 2005; 46 Suppl.8: 184.
Sachdeo R, Porter R, Biton V, Rosenfeld W, Alves W, Nohria V. Dose Finding Study of Retigabine (A Novel AED) in Patients with Epilepsy. Epilepsia 2005; 46 Suppl.8: 185.
Biton V, Sachdeo R, Rosenfeld W, Schachter S, Perdomo C, Arroyo S. Efficacy and Safety of Adjunctive Rufinamide in Patients with Inadequately Controlled Primary Generalized TonicClonic Seizures. Epilepsia 2005; 46 Suppl.8: 206.
Biton V, Vuong A, Kerls S, Hammer A, Messenheimer J. Onset of Efficacy with Lamotrigine in Primary Generalized Tonic- Clonic Seizures (PGTCS): A Randomized, Placebo-Controlled Study. Epilepsia 2005; 46 Suppl.8: 206.
Todorov A, Biton V, Krauss GL, Perdomo C, Arroyo 5. Efficacy and Safety of High- Versus Low-Dose Rufinamide Monotherapy in Patients with Inadequately Controlled Partial Seizures. Epilepsia 2005; 46 Suppl.8: 218- 219.
Biton V, Rosenfeld W, Mameniskiene R, Vaiciene N, Whitesides J, Sommerville K. Safety and Tolerability of Intravenous Lacosamide as Replacement for Oral Lacosamide in Subjects with Partial-Onset Seizures. Epilepsia 2005; 46 Suppl.6: 121.
Ben-Menachem E, Biton V, Jatuzis D, Abou-Khalil B, Doty P, Rudd D, S.P. 667 Study Group. Efficacy and Safety of Adjunctive Oral Lacosamide for the Treatment of Partial Onset Seizures in Patients with Epilepsy. Epilepsia 2005; 46 Suppl.6: 57.
Biton V, Groenke DA, Hammer AE, Kustra RP, Messenheimer JA, Winter P. Evaluation and Comparison of Seizure Control During Escalation of Lamotrigine, Valproic Acid, Carbamazepine and Phenytoin as Initial Monotherapy in Patients with Epilepsy. Eur J Neural 2003; 10(1): 141.
Biton V, Whitesides J, Doty P, Sommerville K. Safety and Efficacy of 5PM 927 during the Initial Phase of an Extension Trial in Subjects with Partial Seizures. Epilepsia 2003; 44 Suppl.9: 259.
Biton V, Bebin ME. Multicenter, Open-Label Assessment of the Efficacy and Safety of Zonisamide as Adjunctive Therapy for Primary Generalized Epilepsy. Epilepsia 2002; 43 Suppl.7: 2.180.
Biton V, Blum D, Groenke D, Hammer A, Messenheimer J. Evaluation and Comparison of Seizure Control During Escalation of Lamotrigine, Valproic Acid, Carbamazepine and Phenytoin as Initial Monotherapy in Patients with Epilepsy. Epilepsia 2002; 43 Suppl.7: 2.183
Biton V. Weight Change Associated with Valproate And Lamotrigine Monotherapy In Patients with Epilepsy. [Letter] Neurology 2001; 57(3): 565-566.
Montouris G, Biton V, Rosenfeld W, YTC/YTCE Study Group. Nonfocal Generalized Tonic-Clonic Seizures: Response During Long-Term Treatment. Epilepsia 2000; 41 Suppl.1: S77-S81.
Mirza W, Biton V, Barrett P, Vuong A, Hammer A. Weight Gain Associated with Valproate Monotherapy in Patients with Epilepsy: An Interim Analysis of a Randomized, DoubleBlinded Comparative Clinical Trial with Lamotrigine. Epilepsia 1999; 40 Suppl.2: 282.
Montouris G, Mirza WU, Biton V, Vuong A, Barrett P, Hammer A. Effects of Lamictal and Depakot Monotherapy on Body Weight in Patients with Epilepsy: Interim Analysis of a Randomized, Double-Blind Clinical Trial. Neurology 1999; 52(6) Suppl.2: A523-A524.
Abou-Khalil BW, Vazquez BR, Beydoun A, Elger CE, Biton V, Krauss GL, Smith TM, Greiner MJ, Knapp LE, Garofalo EA. Pregabalin In-Patient Monotherapy Trial: A Double-Blind, Low-Dose Active-Controlled, Multicenter Study in Patients with Refractory Partial Epilepsy. Neurology 1999; 52(6) Suppl.2: A390.
Biton V, Vasquez B, Sachdeo R, Lenz G, Deaton R, Sommerville K. Adjunctive Tiagabine Compared with Phenytoin and Carbamazepine in the Multicenter, Double-Blind Trial of Complex Partial Seizures. Epilepsia 1998; 39 Suppl.6: 125.
Vazquez B, Abou-Khalil B, Biton V, Smith T, Greiner M, Knapp L, Garofalo E. Pregabalin Monotherapy in Hospitalized Patients: A Study Design for Early Demonstration of Anticonvulsant Efficacy. Epilepsia 1998; 39 Suppl.6: 67.
Biton V, Chadwick D, Montouris GD, Shu-Chen W. Topiramate as Long-Term Therapy in Patients with Generalized Tonic- Clonic Seizures without Focal Onset. Neurology 1998; 50(4) Suppl-4: A311-A312.
Brodie MJ, Biton V, Montouris GD, Shu-Chen W. Topiramate Therapy in Patients with Generalized Tonic-Clonic Seizures without Focal Onset: Long-Term Outcome. Epilepsia 1998; 39 Suppl.2: 2.
Biton V, Montouris GD, Riviello JD, Reife R, & YTC Study Group. Efficacy And Safety Of Topiramate In Generalized Tonic- Clonic Seizures Of Nonfocal Origin. Epilepsia 1997; 38 Suppl.8: 206-207.
Biton V, Montouris GD, Riviello JD, Reife R, & Topiramate YTC Study Group. Topiramate as Add On Therapy in Generalized Seizures of Nonfocal Origin. Ann Neural 1997; 42(3): 502-503.
Sachdeo RC, Biton V, Abou-Khalil B. Seizure-Free Patients in Topiramate Clinical Trials. Epi/epsia 1997; 38 Suppl.7: 13.
Boop FA, Biton V, Souheaver GT, Yasargil MG. Post-operative Verbal memory Performance in Patients Following Dominant Temporal Lobectomy versus Selective Amygdalohippocampectomy. Epilepsia 1997; 38 Suppl.3: 246.
Montouris GD, Biton V, & YTC Study Team. Long-term Topiramate Therapy in Generalized Seizures of Non-focal Origin. Epilepsia 1997; 38 Suppl.3: 82.
Biton V, Montouris GD, & YTC Study Team. Topiramate Double-Blind Trial in Patients with Generalised Tonic-Clonic Seizures Non-focal Origin. Epi/epsia 1997; 38 Suppl.3: 59.
Biton V. Preliminary Open-Label Experience with Topiramate in Primary Generalized Seizures. Epilepsia 1997; 38 Suppl.1: 542-544.
Biton V, Soellner S, Mercante D, Phillips H, Alto G, Sommerville K. Monotherapy with Tiagabine in an Open-Label Study of Partial Seizures. Epilepsia 1996; 37 Suppl.4: 40.
Biton V, Alto G, Pixton G, Sommerville K. Tiagabine Monotherapy in Adults and Children in a Long-Term Study. Epilepsia 1996; 37 Suppl.5: 167.
Biton V, Reife R, Kamin M, Bobrosky K. Topiramate as Add-on Therapy for Patients with Primary Generalized Epilepsy. Neurology 1996; 46: A176.
Schachter 5, Biton V, Soellner S, Edwards K, Cybulski K, Shu V, Hightower B, Sommerville K. Safety and Efficacy of Tiagabine HCI Monotherapy in the Treatment of Partial Seizures: High Dose versus Low Dose. Epilepsia 1995; Vol. 361 Suppl.3: 5148.
Sachdeo RC, Biton V, Boellner SW, Schachter SC, Alto G, Kaply C, Philips HB, Kardatzke D, Pixton G, Sommerville KW. Long Term Safety of Tiagabine HCI. Epilepsia 1995; Vol. 36, Suppl.4: 55.
Schachter S, Biton V, Bergen D, Ahmann P, Rask CA, Smith S, Deaton R, Patterson R. Long-Term Safety of Tiagabine HCI. Epilepsia 1993; 34, Suppl.6: 67.
Biton V, Boop R. Ethotoin -A Last Resort Anti-Epileptic Drug. Epilepsia 1991; 32, Suppl.3: 61.
Biton V, Fiol M, Gates J. Do lctal Events Originate from Areas of lnter-lctal Activity? A Chronically Implanted Subdural Electrode Study. Epilepsia 1989 Oct; (30 )5: 694.
Fiol M, Gates J, Biton V, Maxwell R. The Value of Subdural Electrode Array in the Surgical Treatment of Patients with Widespread Temporal Lobe lnterictal Activity or Solitary Mid posterior Temporal MRI Lesions. Epilepsia 1989; (30)5: 694.
Biton V, Fiol M, Gates J, Maxwell R. Inhibitory Sensory Locus Defined by Direct Cortical Stimulation. J Clin Neurophysiol 1988; (5)4: 338-339.
Biton V, Abramsky O. Newer Study Fails to Support Environmental Factors in Etiology of Multiple Sclerosis. Neurology 1986; 36: 184.
Melamed E, Biton V, Zelig 0. Less Recognized Side Effects of Chronic Dopatherapy that may be caused by Faculty Absorption of L-Dopa: studies in Parkinsonian Fluctuators. Neurology 1985; 232 Suppl: 192.
Melamed E, Biton V. Delayed Onset of Responses to Individual Doses of L-Dopa in Parkinsonian Fluctuators: An Additional Side Effect of Long Term L-Dopa Therapy. Neurology 1984; 34 Suppl.2: 270.
Abbott Laboratories. Protocol Mo1-274. Principal Investigator.
A Comparison of the Bioavai/ability of a Depakote ER Formulation Relative to the Depakote DR Tablet Formulation in Adult Patients with Epilepsy on the Depakote DR Tab/et Formulation and an Enzyme-Inducing Antiepileptic Drug.
Abbott Laboratories. Protocol Mo1-313. Principal Investigator.
An Evaluation of the Pharmacol Profile and Safety of Depakote Extended-Release Tablets in Pediatric Patients.
Abbott Laboratories. Protocol Mo3-654. Principal Investigator.
A 24-Week, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Dose Finding, Safety, Tolerability, and Efficacy Study of the Human Anti-lL-12 Antibody ABT-874 in Subjects with Multiple Sclerosis with a 24-Week Double-Blind, Active Extension Phase.
Abbott Laboratories. Protocol M91-604. Principal Investigator.
An Open-Label Extension Study of Tiagabine HCI in the Treatment of Patients with Partial Seizures.
Abbott Laboratories. Protocol M92-813. Principal Investigator.
An Open-Label Study of the Safety of Long Term Tiagabine HCI Administration in Patients with Epilepsy.
Abbott Laboratories. Protocol M92-825. Principal Investigator.
Safety and Efficacy of Tiagabine HCI as Adjunctive Treatment.
Abbott Laboratories. Protocol M96-421. Principal Investigator.
Safety and Efficacy of Tiagabine HCI in the Treatment of Pediatric Patients with Partial Seizures.
Abbott Laboratories. Protocol M97-655. Principal Investigator.
Safety and Efficacy of Gabitri/ (Tiagabine HCI) as Adjunctive Treatment to Non-Hepatic Enzyme Inducing Antiepileptic Drugs.
Abbott Laboratories. Protocol M99-114. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Comparison of the Safety and Efficacy of ABT-594 to Placebo in Subjects with Painful Diabetic Polyneuropathy.
Accera, Inc. Protocol AC-12-010. Victor Biton, Principal Investigator.
A 26-Week, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Investigate the Effects of Daily Administration of AC-1204 in Participants with Mild to Moderate Alzheimer’s Disease (AD) with an Optional 26-Week Open-Label Extension.
Acorda Therapeutics, Inc. Protocol DZNS-EP-1019. Principal Investigator.
An Open-Label, Randomized, Crossover Pharmacokinetic Study to Determine Relative Bioavailability, Safety and Tolerability of Single Doses of Diazepam Nasal Spray Versus Diazepam Rectal Gel (Diastat®) in Patients with Refractory Epilepsy.
Acorda Therapeutics, Inc. Protocol DZNS-EP-1025. Principal Investigator.
An Open-Label, Safety and Tolerability Study of Chronic Intermittent Use of Diazepam Nasal Spray in Adolescents and Adults with Cluster Seizures.
Allergan. Protocol AGN 203818-004. Principal Investigator.
A Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Multiple Dose, Parallel Design, Dose Ranging Study of the Safety and Efficacy of AGN 203818 in Patients with Painful Diabetic Peripheral Neuropathy.
Astellas Pharma, Inc. Protocol 03-0-189. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase II Study to Evaluate the Safety and Efficacy of FK962 in Subjects with Mild-to-Moderate Alzheimer’s Disease.
Astra Merck, Inc. Protocol 134. Principal Investigator.
A Comparator Dose Controlled, Ascending Multiple Dose Safety and Tolerability Study of Remacemide Hydrochloride as an Adjunctive Therapy on Refractory Patients with Epilepsy.
Astra Merck, Inc. Protocol 201. Principal Investigator.
An Interaction Study Between H199/18 and Phenytoin in Epileptic Patients.
Civitas Therapeutics, Inc. Protocol CVT-301-003. Principal Investigator.
A Phase 2b, Randomized, Double-blind, Placebo-controlled Study Investigating the Efficacy and Safety of Inhaled CVT-301 (Levodopa Inhalation Powder) in Parkinson’s Disease Patients with Motor Response Fluctuations (OFF Phenomena).
Cyberonics. Protocol E-20. Principal Investigator.
A Randomized, Parallel-Group Comparison of Treatment with Pharmacotherapy or Adjunctive Vagus Nerve Stimulation Therapy for Pharmacoresistant Partial Seizures: A Large Simple Effectiveness Trial.
Daichii Sankyo. Protocol DS5565-A-U201. Principal Investigator.
A Randomized, Double-Blind, Placebo and Active Comparator-Controlled Study of DS-5565 for Treatment of Neuropathic Pain Associated with Diabetic Peripheral Neuropathy.
Dainippon Sumitomo Pharma Co., Ltd. Protocol AC-3933-271. Principal Investigator.
A Phase II, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Dose-Ranging Study Assessing the Efficacy and Safety of AC-3933 Tablets Twice Daily in Adults with Mild-to Moderate Alzheimer’s Disease.
Depomed, Inc. Protocol 81-0046. Principal Investigator.
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Gabapentin Extended Release (G-ER) Tablets in the Treatment of Patients with Painful Diabetic Peripheral Neuropathy.
Depomed, Inc. Protocol 81-0068. Principal Investigator.
A Phase 2, Randomized, Open-Label, Crossover Study to Compare DM-1992, a Novel Gastric-Retentive Extended-Release Formulation of Levodopa/Carbidopa, to an Immediate-Release Carbidopa/Levodopa Tab/et in Patients with Advanced Parkinson’s Disease with Motor Fluctuations.
Eisai Medical Research, Inc. Protocol E2007-Aoo1-206. Principal Investigator.
A Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel-Group Study of E2007 Given as Adjunctive Therapy in patients with Refractory Partial Seizures.
Eisai Medical Research, Inc. Protocol E2007-Aoo1-207. Principal Investigator.
A 4-Year Open-Label Extension Phase of the Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel-Group Study of E2007 as an Adjunctive Therapy in Patients With Refractory Partial Seizures (revised per Amendment 02, 03, and 05).
Eisai Medical Research, Inc. Protocol E2007-Aoo1-214. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Explore the Safety and Tolerability of Doses of E2007 Up to a Maximum of 6mg in Patients with Parkinson’s Disease Who Experience End-of-Dose “Wearing-Off” Motor Fluctuations.
Eisai Medical Research, Inc. Protocol E2007-Aoo1-220. Principal Investigator.
A Mutt/center, Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of E2007 in Patients with Parkinson’s Disease Who Experience End-of-Dose ‘WearingOff’ Motor Fluctuations.
Eisai Medical Research, Inc. Protocol E2007-Aoo1-302. Principal Investigator.
A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy, Safety, and Tolerability of E2007 in Levodopa Treated Parkinson’s Disease Patients with Motor Fluctuations.
Eisai Medical Research, Inc. Protocol E2007-Gooo-303. Principal Investigator.
A Multi-Centre, Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of E2007 as an Adjunctive Therapy in Levodopa Treated Parkinson’s Disease Patients with Motor Fluctuations.
Eisai Medical Research, Inc. Protocol E2007-Gooo-304. Principal Investigator.
A Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel-Group Study to Evaluate the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects with Refractory Partial Seizures.
Eisai Medical Research, Inc. Protocol E2007-Gooo-307. Principal Investigator.
A 14-Month Open-Label Extension Phase of the Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel-Group Studies to Evaluate the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects with Refractory Partial Seizures.
Eisai Medical Research, Inc. Protocol E2007-Gooo-332. Principal Investigator.
A Double-blind, Randomized, Placebo-controlled, Multicenter, Parallel-group Study with an Open label Extension Phase to Evaluate the Efficacy and Safety of Adjunctive Perampanel in Primary Generalized Tonic-Clonic Seizures.
Eisai Medical Research, Inc. Protocol E2080-Aoo1-301. Principal Investigator.
A Double-Blind, Placebo-Controlled, Parallel-Group Study of Rufinamide Given as Adjunctive Therapy in Patients with Refractory Partial Seizures.
Eisai Medical Research, Inc. Protocol E2080-Aoo1-302. Principal Investigator.
An Open-Label Extension Study of Rufinamide Given as Adjunctive Therapy in Patients with Refractory Partial Seizures.
Elan Pharmaceuticals, Inc. Protocol ELN115727-301. Principal Investigator.
A Phase Ill, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Efficacy and Safety Trial of Bapineuzumab (AAB 001, ELN115727) in Patients with Mild-to-Moderate Alzheimer’s Disease Who Are Apolipoprotein E £4 Non-Carriers.
Elan Pharmaceuticals, Inc. Protocol ELN115727-302. Principal Investigator.
A Phase Ill, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Efficacy and Safety Trial of Bapineuzumab (AAB 001, ELN115727) in Patients with Mild-to-Moderate Alzheimer’s Disease Who Are Apolipoprotein E £4 Carriers.
Elan Pharmaceuticals, Inc. Protocol ELN115727-351. Principal Investigator.
A Phase 3 Extension, Multicenter, Double-Blind, Long Term Safety and Tolerability Treatment Trial of Bapineuzumab (AAB-001, ELN115727) in Subjects with Alzheimer’s Disease who Participated in Study £LN115727-301 or in Study ELN115727-302.
Elan Pharmaceuticals, Inc. Protocol ZNS-501. Principal Investigator.
A Multicenter, Open-Label, Assessment of the Safety of Zonegran ‘” as Adjunctive Therapy in Patients with Primary Generalized Epilepsy.
Eunoe, Inc. Protocol 2000-01. Principal Investigator.
A Prospective, Randomized Start, Multi-Center, Double-Blinded, Concurrently Placebo-Controlled Study to Evaluate the Effect of Flow-Regulated Ventriculoperitoneal Shunting on Progression of Alzheimer’s Disease: an Investigation of the Safety and Effectiveness of the COGNIShunt™ CNS Fluid Shunt System.
Eunoe, Inc. Protocol 2000-01 E. Principal Investigator.
Long-term Follow-on Safety Evaluation of the Cognishunt® CNS Fluid Shunt System Implanted under Pivotal Study 2000-01 in Subjects with Alzheimer’s Disease.
Forest Laboratories, Inc. Protocol MEM-MD-06. Principal Investigator.
An Evaluation of the Safety and Efficacy of Memantine in the Treatment of Chronic Pain in Patients with Painful Diabetic Neuropathy.
Forest Research Institute. Protocol RG8-M D-02. Principal Investigator.
A Randomized, Double-Blind, Placebo and Active Controlled Study of the Safety and Efficacy of RGH-896 in Patients with Diabetic Peripheral Neuropathic Pain.
FORUM Pharmaceuticals. Protocol EVP-6124-025. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 26-Week, Phase 3 Study of Two Doses of EVP-6124 or Placebo in Subjects with Mild to Moderate Alzheimer’s Disease Currently or Previously Receiving an Acetylcho/inesterase Inhibitor Medication.
FORUM Pharmaceuticals. Protocol EVP-6124-026. Principal Investigator.
A 26-Week Extension Study of the Safety and Clinical Effects of EVP-6124 in Subjects with Alzheimer’s Disease Currently or Previously Receiving an Acetylcholinesterase Inhibitor Medication.
Fujisawa. Protocol 03-0-189. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase 2 Study to Evaluate the Safety and Efficacy of FK962 in Subjects with Mild to Moderate Alzheimer’s Disease.
Genentech, Inc. Protocol Ko622g. Principal Investigator.
A Phase II, Mu/ticenter, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Safety and Efficacy of Recombinant Human Nerve Growth Factor in Patients with Diabetic Peripheral Polyneuropathy.
Genentech, Inc. Protocol Ko717g. Principal Investigator.
An Open-Label Extension Study of the Long Term Safety of Recombinant Human Nerve Growth Factor in the treatment of Subjects with Diabetic Neuropathy.
Genentech, Inc. Protocol Ko718g. Principal Investigator.
A Phase Ill, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group Study of the Efficacy and Safety of Recombinant Human Nerve Growth Factor in Subjects with Diabetic Neuropathy.
Genentech, Inc. Protocol Ko807g. Principal Investigator.
A Phase Ill, Open-Label Extension Study of the Long-Term Safety of Recombinant Human Nerve Growth Factor (rhNGF) in Treatment of Subjects with Diabetic Neuropathy.
Genzyme. Protocol CAMMS223. Principal Investigator.
A Phase 11, Randomized, Open-Label, Three-Arm Study Comparing Low- and High-Dose CAMPATH (MABCAMPATH) and High-Dose Rebif in Patients with Early, Active Relapsing-Remitting Multiple Sclerosis.
GlaxoSmithKline. Protocol 164. Principal Investigator.
An Open-Label, Randomized, Two-Part Study to Investigate the Relative Bioavailability of Ropinirole CR and IR Formulations and the Effect of Food on the Pharmacol
GlaxoSmithKline. Protocol AVA102670. Principal Investigator.
A 54-Week, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Investigate the Effects of Rosiglitazone (Extended Release Tablets) as Adjunctive Therapy to Acetylcholinesterase Inhibitors on Cognition and Overall Clinical Response in APO£ 04- Stratified Subjects with Mild-to-Moderate Alzheimer’s Disease (REFLECT-3).
GlaxoSmithKline. Protocol AVA102675. Principal Investigator.
A 52-Week Open-Label Extension Study of the Long-Term Safety and Efficacy of Rosiglitazone Extended-Release (RSG XR) as Adjunctive Therapy to Acety/cholinesterase Inhibitors in Subjects with Mild-to-Moderate Alzheimer’s Disease (REFLECT-4).
GlaxoSmithKline. Protocol LAM 100034. Principal Investigator.
A Multi-Center, Double-Blind, Randomized, Parallel-Group Evaluation of Lamictal Extended Release Adjunctive Therapy in Patients with Partial Seizures.
GlaxsoSmithKline. Protocol PXN110448. Principal Investigator.
A Dose Response Study of XP13512, Compared with Concurrent Placebo Control and Pregabalin (Lyrica), in Subjects with Neuropathic Pain Associated with Diabetic Peripheral Neuropathy.
GlaxoSmithKline. Protocol LAM 100036. Principal Investigator.
A Multi-Center, Double-Blind, Randomized, Parallel-Group Evaluation of Lamictal Extended Release Adjunctive Therapy in Patients with Primary Generalized Tonic-Clonic Seizures.
GlaxoSmithKline. Protocol LAM40013. Principal Investigator.
A Multicenter, Open-Label Conversion of Valproate Monotherapy to Lamotrigine Monotherapy in Patients with Epilepsy.
GlaxoWellcome. Protocol LAM40097. Principal Investigator.
A Multi-Center, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Evaluation of Lamotrigine Adjunctive Therapy in Subjects with Primary Generalized Tonic-Clonic Seizures.
GlaxoSmithKline. Protocol LAM40112. Principal Investigator.
A Double-Blind, Randomized Trial of Cognitive Effects of Lamictal (Lamotrigine) Versus Topiramate in Epilepsy.
GlaxoSmithKline. Protocol NPP30004. Principal Investigator.
A Multicenter, Double-blind, Randomized Study to Evaluate the Safety and Efficacy of Lamotrigine 2oomg/day, 3oomg/day and 4oomg/day Compared with Placebo in Subjects with Painful Diabetic Neuropathy.
GlaxoSmithKline. Protocol NPP30006. Principal Investigator.
An Open-Label Extension Study to Evaluate the Safety of Lamotrigine in Subjects with Painful Diabetic Neuropathy.
GlaxoSmithKline. Protocol NPP30010. Principal Investigator.
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of Lamotrigine in Subjects with Neuropathic Pain and Inadequate Pain Relief with Gabapentin, Tricyclic Antidepressants or Non-Narcotic Analgesics.
GlaxoWellcome. Protocol SCAA2001. Principal Investigator.
A Pilot Open-Label Evaluation of the Safety, Tolerability, and Efficacy of Add-On 534U87 Treatment of Partial Seizures.
GlaxoWellcome. Protocol SCAA4001. Principal Investigator.
A Double-Blind, Double-Dummy, Parallel-Group Comparison of Lamotrigine and Divalproex Sodium Monotherapy in Patients with Generalized Seizures.
Hoechst Marion Roussel, Inc. Protocol 071754PRO223 Principal Investigator.
A Dose Response Study of Efficacy and Safety of Vigabatrin 1, 3, 4, and 6 gm/day as Monotherapy in Patients with Complex Partial Seizures.
Hoechst Marion Roussel, Inc. Protocol 071754PRO242. Principal Investigator.
An Open-Label, Follow-Up, Long-Term Maintenance Study of Vigabatrin as Monotherapy in Patients with Complex Partial Seizures.
Hoechst Marion Roussel, Inc. Protocol VGPR0098/VGST1245. Principal Investigator.
Clinical Experience and Use of Sabril in Patients with Partial Seizures.
lcagen. Protocol lCA-105665-02. Principal Investigator.
A Phase 1, Mu/ti-Center, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability, and Pharmacokinetics of Escalating Multiple Oral Doses of ICA-105665 in Healthy Subjects and in Patients with Epilepsy.
lcagen. Protocol lCA-105665-04. Principal Investigator.
A Phase 2, Multi-Center, Single-Blind, Placebo-Controlled Pharmacodynamic Evaluation of /CA-105665 in Epilepsy Patients with a Photo-Induced Paroxysmal EEG Response.
lkano. Protocol MZ0917. Principal Investigator.
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Cross-Over Study of the Safety and Efficacy of Intranasal Midazolam in the Outpatient Treatment of Subjects with Seizure Clusters.
ILEX Pharmaceuticals. Protocol CAMMS223-A1. Principal Investigator.
A Phase II, Randomized, Open-Label, Three-Arm Study Comparing Low- and High-Dose CAMPA TH® (MABCAMPATH®) and High-Dose Rebif® in Patients with Early, Active Relapsing-Remitting Multiple Sclerosis.
Impax. Protocol lPX066-B09-02. Principal Investigator.
A Study to Evaluate the Safety and Efficacy of IPXo66 in Advanced Parkinson’s Disease.
lmpax. Protocol lPX066-B09-03. Principal Investigator.
An Open-Label Extension Study of the Safety and Clinical Utility of IPXo66 in Subjects with Parkinson’s Disease.
lmpax. Protocol lPX203-B14-02. Principal Investigator.
A Study to Assess The Pharmacokinetics and Pharmacodynamics of Single Dose of IPX203 In Patients With Advanced Parkinson’s Disease.
lmpax. Protocol I PX203-B16-01. Principal Investigator.
A Randomized, Multiple Dose Study to Assess the Pharmacokinetics and Pharmacodynamics of /PX203 in Subjects with Advanced Parkinson’s Disease.
lnsmed Inc. Protocol lNS1-DM-28. Principal Investigator.
A Randomized, Multicenter, Double-Blind, Parallel-Group Clinical Study to Compare the Effects of JNS-1 (D-Chiro-lnositol) versus Placebo as Oral Therapy in Subjects with Type 2 Diabetes Mellitus Who Fail to Achieve Adequate Glycemic Control with Diet and Exercise.
Intranasal Therapeutics, Inc. Protocol MZ0815. Principal Investigator.
A Randomized Open-Label Study to Determine the Safety, Tolerability and Pharmacokinetics of Ascending Single Doses and Two Doses of Intranasal Midazolam in Subjects with Epilepsy.
Ivax Laboratories. Protocol IXL-201-14-189. Principal Investigator.
Efficacy and Safety of T alampanel as Adjunctive Therapy in Patients with Partial Seizures: a Phase II Clinical Trial.
Ivax Laboratories. Protocol IXL – 201 F-14 -189. Principal Investigator.
Talampanel Open-Label Adjunctive Therapy: A Follow-On Study to Determine Long-Term Safety and Efficacy in Patients with Partial Seizures.
Jazz Pharmaceuticals, Inc. Protocol 06-001. Principal Investigator.
A Non-Randomized, Within Subject, Placebo-Controlled Exploratory Study of the Effects of JZP-4 on the Photic-lnduced Paroxysmal EEG Response in Patients with Photosensitive Epilepsy.
Jazz Pharmaceuticals, Inc. Protocol 07-001. Principal Investigator.
A Phase 2a, Open-Label, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Intranasal Clonazepam in Adult Subjects with Epileptic Seizures.
Johnson & Johnson Pharmaceutical Research & Development.
Protocol 333369-EPY-2001; 333369-EPY-2002. Principal Investigator.
A Double Blind, Placebo-Controlled, Dose-Titration Study to Determine Safety, Tolerability and Preliminary Efficacy of RWJ-333369 as Adjunctive Therapy in Subjects with TreatmentResistant Partial Seizures (with or without Secondary Generalization) or Primarily Generalized Tonic-Clonic Seizures.
Johnson & Johnson Pharmaceutical Research & Development.
Protocol 333369-EPY-2003; 333369-EPY-2006. Principal Investigator.
A Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy, Safety, and Tolerability of RWJ-333369 as Adjunctive Therapy in Subjects with Refractory Partial Seizures.
Johnson & Johnson Pharmaceutical Research & Development.
Protocol 333369-EPY-3001; 3333609-EPY-3004. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy, Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Subjects with PartialOnset Seizures Followed by an Open-Label Extension Study.
King Pharmaceuticals/Pfizer. Protocol K826-05-3001. Principal Investigator.
A Phase Ill, Randomized, Double-Blind, Parallel, Placebo-Controlled, Multi-Center Study, with Optional Open-Label Continuation, of the Efficacy and Safety of Vanquix™ Auto-Injector (Diazepam Injection) for the Management of Selected, Refractory, Patients with Epilepsy Who Require Intermittent Medical Intervention to Control Episodes of Acute Repetitive Seizures.
Lorex Pharmaceuticals. Protocol LESO1. Principal Investigator.
An Evaluation of the Efficacy and Safety of Eli prod ii in Patients with Acute lschemic Stroke.
Lundbeck. Protocol 13181A. Principal Investigator.
An Open-Label Study to Assess the Safety and Tolerability of Intravenous Carbamazepine as Short Term Replacement of Oral Carbamazepine in Adult Patients with Epilepsy.
Lundbeck. Protocol 14861A. Principal Investigator.
Randomised, Double-Blind, Parallel-Group, Placebo-Controlled, Fixed-Dose Study of Lu AE58054 in Patients with Mild-Moderate Alzheimer’s Disease Treated with Donepezil.
Lundbeck. Protocol 14861B. Principal Investigator.
An Open-Label Extension Study to Evaluate the Long-Term Safety and Tolerability of Lu AE58054 as Adjunctive Treatment to Donepezil in Patients with Mild-Moderate Alzheimer’s Disease.
Marinus Pharmaceuticals, Inc. Protocol 1042-0600. Principal Investigator.
A Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Ganaxo/one as Add-on Therapy in Adult Subjects with Epilepsy Consisting of Uncontrolled Partial-Onset Seizures.
Marinus Pharmaceuticals, Inc. Protocol 1042-0601. Principal Investigator.
An Open-Label Extension Study to Evaluate the Safety, Tolerability, and Efficacy of Ganaxalone as Add-On Therapy in Adult Patients with Epilepsy Consisting of Uncontrolled Partial-Onset Seizures.
Marinus Pharmaceuticals, Inc. Protocol 1042-0603. Principal Investigator.
A Multicenter, Double Blind, Randomized, Placebo-Controlled Trial to Determine the Efficacy and Safety of Ganaxolone as Adjunctive Therapy for Adults with Drug-Resistant Partial-Onset Seizures Followed by Long-term Open-Label Treatment.
Medivation. Protocol DIM 18. Principal Investigator.
A Phase 3 Multicenter, Randomized, Placebo-Controlled, Double-Blind Twelve-Month Safety and Efficacy Study Evaluating Dimebon in Patients with Mild-to-Moderate Alzheimer’s Disease on Donepezil.
Medivation. Protocol DIM 18 EXT. Principal Investigator.
An Open-Label Extension of the CONCERT Protocol (D/M18) Evaluating Dimebon (Latrepirdine) in Patients with Alzheimer’s Disease.
Merck. Protocol 021-00. Principal Investigator.
A Phase Ila, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial to Evaluate the Safety and Efficacy of MK-6096 in Patients with Painful Diabetic Neuropathy.
Merck. Protocol MK-7622-012. Principal Investigator.
A Seamless Phase Ila/lib, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial to Evaluate the Efficacy and Safety of MK-7622 as an Adjunctive Therapy to Donepezil for Symptomatic Treatment in Subjects with Alzheimer’s Disease.
Myriad Pharmaceuticals, Inc. Protocol MPC-7869-04-005. Principal Investigator.
A Phase Ill, Randomized, Double-Blind, Placebo-Controlled, Study of the Effect of Daily Treatment with MPC-7869 on Measures of Cognitive and Global Function in Subjects with Mild-toModerate Dementia of the Alzheimer’s Type.
Nestle Health Science-Pamlab, Inc. Protocol M-003. Principal Investigator.
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial to assess the safety and nutritional benefits of Metanx® in Subjects with Diabetic Peripheral Neuropathy (MEDIAN Study).
Neurelis. Protocol DIAZ.001.05. Principal Investigator.
A 12-Month, Open-Label, Repeat-Dose Safety Study of NRL-1 in Epilepsy Subjects.
Novartis Pharmaceuticals. Protocol CRUF3310038. Principal Investigator.
A Multicenter, Double-Blind, Randomized, Placebo-Control, Parallel-Group, Monotherapy Study of Rufinamide in Patients with Refractory Partial Seizures Who Have Completed an Evaluation for Epilepsy Surgery.
Novartis Pharmaceuticals. Protocol CRUF3310039. Principal Investigator.
Multicenter, Double-Blind, Randomized, Placebo-Control, Parallel-Group Monotherapy Study of Rufinamide in Patients with Recent-Onset Partial Seizures.
Novartis Pharmaceuticals. Protocol 3310101016. Principal Investigator.
Safety and Efficacy of High-Versus Low-Dose Rufinamide Monotherapy in Patients with Inadequately Controlled Partial Seizures.
Novartis Pharmaceuticals. Protocol 3310101018. Principal Investigator.
A Multicenter, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Trial of Rufinamide as Adjunctive Therapy in Patients with Inadequately Controlled Primary Generalized Tonic-Clonic Seizures.
NPS Pharmaceuticals, Inc. Protocol CL1776-014. Principal Investigator.
A Proof of Concept Phase II Study of the Efficacy and Safety of Various Plasma Levels of lsovaleramide in the Photic Model in Subjects with Photosensitive Epilepsy.
Ortho-McNeil Pharmaceutical. Protocol CAPSS-027. Principal Investigator.
A Double-Blind, Placebo Controlled, Parallel Study to Evaluate the Efficacy of Topamax@ (Topiramate) Compared to Valproate as Add-On Therapy to Carbamazepine with Special Emphasis on Cognitive Function in Subjects with Partial-Onset Seizures.
Ortho-McNeil Pharmaceutical. Protocol CAPSS-272. Principal Investigator.
A Double-Blind Trial Comparing the Efficacy, Tolerability and Safety of Monotherapy Topiramate Versus Phenytoin in Subjects with Seizures Indicative of New-Onset Epilepsy.
Ortho-McNeil Pharmaceutical. Protocol TPS-TR/TPS-TR ext. Principal Investigator.
A Randomized, Double-Blind, Parallel-Design, Multicenter Trial to Evaluate Two Titration Rates of Oral Topamax (Topiramate) in Subjects with Epilepsy.
Ovation Pharmaceuticals. Protocol OV-1015. Principal Investigator.
A Sequential, Open-Label Study of the Pharmacokinetics and Safety of Intravenous Carbamazepine Relative to Oral Carbamazepine in Adult Patients with Epilepsy.
Parke-Davis Pharmaceutical Research. Protocol 1008-007. Principal Investigator.
A Pregabalin In-Patient Monotherapy Trial: a Double-Blind, Positive-Controlled, Multicenter Study in Patients with Refractory Partial Epilepsy.
Parke-Davis Pharmaceutical Research. Protocol 1008-008. Principal Investigator.
A Pregabalin Open-Label, Follow-On Safety Trial in Patients with Refractory Partial Epilepsy.
Parke-Davis Pharmaceutical Research. Protocol 1008-009. Principal Investigator.
A Pregabalin Add-On Trial: a Double-Blind, Placebo-Controlled, Multicenter Study in Patients with Partial Seizures.
Parke-Davis Pharmaceutical Research. Protocol 1008-010. Principal Investigator.
A Pregabalin Open-Label Add-On Trial: an Open-Label, Multicenter Follow-On Study to Determine
Long-Term Safety and Efficacy in Patients with Partial Seizures.
Parke-Davis Pharmaceutical Research. Protocol 1008-029. Principal Investigator.
A 5-Week, Double-Blind, Placebo-Controlled Trial of 3 Dosages of Pregabalin (75, 300, 6oomg/day) for Treatment of Painful Diabetic Peripheral Neuropathy.
Parke-Davis Pharmaceutical Research. Protocol 1008-033. Principal Investigator.
A Pregabalin Open-Label, Extension Safety Trial in Patients with Chronic Pain.
Pfizer. Protocol Aoo81096. Principal Investigator.
Prospective Randomized 12-Week Controlled Study of Visual Field Change in Subjects with Partial Seizures Receiving Pregabalin or Placebo.
Pfizer. Protocol Aoo81194. Principal Investigator.
A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Mu/ti-Center Trial of Pregabalin Controlled Release Formulation as Adjunctive Therapy in Adult Patients with Partial Onset Seizures.
Pfizer. Protocol A4091031. Principal Investigator.
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel Group, Proof-of-Concept Study of the Analgesic Effects of Tanezumab in Adult Patients with Diabetic Peripheral Neuropathy.
Pfizer. Protocol B1451027. Principal Investigator.
A Phase 31 Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Tolerability of Dimebon (PF-01913539) for up to 26 Weeks In Patients with Mild-toModerate Alzheimer’s Disease.
Pfizer. Protocol B1451029. Principal Investigator.
An Open-Label Extension to the 81451027 Protocol to Evaluate the Long-Term Safety and Tolerability of Dimebon (PF-01913539) In Patients with Alzheimer’s Disease.
Pfizer. Protocol M/2760/001. Principal Investigator.
Sumanirole: Open-Label, Long Term, Flexible Dose Study of Safety, Tolerability and Therapeutic Response in Patients with Parkinson’s Disease.
Pharmacia & Upjohn. Protocol 666E-CNS-0075-021. Principal Investigator.
A Phase Ill, Double-Blind, Placebo-Controlled, Randomized Study Comparing the Efficacy, Safety, and Tolerability of Sumanirole Versus Placebo or Ropinirole in Patients with Early Parkinson’s Disease.
Pharmacia & Upjohn. Protocol M/2760/0009. Principal Investigator.
A Double-Blind, Placebo-Controlled, Dose Response Study of Tolerability, Safety, and Efficacy in Patients with Early Parkinson’s Disease.
Pharmacia & Upjohn. Protocol M/2760/0011. Principal Investigator.
An Open-Label, Long Term, Flexible Dose Study of Safety, Tolerability, and Therapeutic Response in Patients with Parkinson’s Disease.
R.W. Johnson Pharm. Research Inst. Protocol TOPMAT-EPMN-104. Principal Investigator.
A Topiramate Monotherapy Clinical Trial in Subjects with Recently Diagnosed Partial-Onset Seizures.
Tramadol with Acetaminophen in the Pain of Osteoarthritis of the Hip and Knee.
Tramadol with Acetaminophen in Low Back Pain of Non-Malignant Origin.